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8 Signs of Inflammatory Alzheimer’s Disease

Poor Short Term Memory

Difficulty learning new things and storing new memories and information.

Better Long Term Memory

No problems recalling memories from when you were younger.

Brain Volume Loss

Measurable loss in the hippocampus region of the brain.

ApoE Genetic Risk

One copy of ApoE4 gives you a 30% chance of getting AD. Two copies give you a 50% chance.

Elevated Inflammatory Markers

High levels of CRP, IL -6, and TNF seen in labs.

Decreased A/G Ratio

Decreased ability to remove toxins and amyloid.

Insulin Resistance

Elevated insulin levels indicating some degree of insulin resistance.

Impaired Methylation

Restricted ability to utilize vitamin B12 and folate.

Subtype No. 1


Alzheimer’s Disease

Inflammation is a buzzword that is trending for good reason—inflammation affects every part of your body!

Chronic inflammation is a primary contributor to neurodegeneration and Alzheimer’s disease, specifically the inflammatory subtype.




Inflammation is a critical process in your body that protects you from infection and allows you to heal from injury. It consists of a well-orchestrated series of events triggered inside you by your immune system, cells with names like T-cells, B-cells, antibodies, cytokines, natural killer cells, etc.

Without a properly functioning inflammatory system, you wouldn’t survive for long.




When inflammation isn’t turned off appropriately and thus becomes chronic, you can develop conditions like cardiovascular disease, arthritis, diabetes, cancer, and inflammatory bowel conditions (i.e. Crohn’s, Ulcerative Colitis).

This is true for a large subtype of people with Alzheimer’s disease as well.

“Inflammation can wreak havoc throughout your whole body, but the damage it can do to your brain is the most devastating. However, we now know that inflammation can be systematically reduced through a combination of lifestyle and nutritional interventions, minimizing the risk of Inflammatory Alzheimer’s.”

Dr. Scott Noorda, DO

Family Physician, Precision Medicine

Signs + Symptoms


Typically this type of Alzheimer’s Disease begins with the loss of ability to store new information and new memories, and also a harder time learning new things. Interestingly, long term memory is not lost, especially in the earlier stages of the disease process.

This means that people can recall details of events that happened 30, 40, or even 50 years ago, but may not be able to remember their conversation from five minutes ago. They also initially retain their ability to speak, perform mathematical calculations, spell, and write.

When an MRI is performed, the area where brain volume loss (atrophy) is most apparent is in the hippocampus, while other brain areas are typically spared. The hippocampus, named for its seahorse-like appearance, was traditionally thought to be the storage place for long term memories.

However, scientists have discovered that the hippocampus, together with its extensive connections with other areas of the brain, plays a much more complex role that includes not only memory, but also navigation skills, imagination & creativity, decision-making, character judgments, establishing and maintaining social bonds, empathy, social skills, and language use.

Genetic Factors


Some subtypes of Alzheimer’s are more commonly associated with specific genetic susceptibilities. This is true for the inflammatory subtype, which is more commonly associated with the higher risk ApoE4 gene, whether homozygous (two copies) or heterozygous (single copy).

We each receive two copies of the ApoE gene (one from each parent), and the possibilities are ApoE2, 3, or 4. It is most common for people to inherit two copies of the ApoE3 gene, which carries with it just a 9% risk of developing Alzheimer’s disease.

In contrast, having a single copy of the ApoE4, which is seen in about 25% of Americans, increases one’s genetic risk to 30%. Having two copies of ApoE4, seen in a little over 2% of the U.S. population, increases the risk to greater than 50%. Individuals with ApoE4 genes appear to be most likely to develop the inflammatory subtype of Alzheimer’s.

People who inherit two copies of the ApoE4 gene typically begin experiencing symptoms at a younger age, with their onset typically in their late forties or fifties. With just one copy of this gene, the onset is about a decade late. With no ApoE4 gene, the onset is more often in their upper sixties or seventies.

Lab Indications


Different subtypes can’t always easily be distinguished by lab testing, but there are some unique findings in the inflammatory subtype that are worth mentioning. As expected, markers of inflammation like the CRP (c-reactive protein), IL-6, and TNF are often elevated.

The ratio of albumin to globulin (A/G ratio) is frequently decreased. This is important because albumin is an important protein in the blood for removing toxins and other detrimental molecules (including amyloid) from the body, and a lower ratio means this removal isn’t happening as it should.

Insulin levels may be elevated, showing at least some degree of insulin resistance developing in the body. Homocysteine levels are also often elevated, suggesting that a process of activating and utilizing vitamin B12 and folate (called methylation) is not working efficiently.

Target levels for these nutrients and biomarkers aren’t always the levels shown as normal by different lab companies. Discuss them with a practitioner trained in optimizing and personalizing these lab findings.

Alzheimer’s Prevention Articles

Rubin, R. D., Watson, P. D., Duff, M. C., & Cohen, N. J. (2014). The role of the hippocampus in flexible cognition and social behavior. Frontiers in human neuroscience, 8, 742.
Bredesen, D. (2017). The End of Alzheimer’s: The first program to prevent and reverse cognitive decline. Penguin. p. 102.